Diamox (acetazolamide) is the most popular drug that is used to alleviate the symptoms of altitude sickness in the case of trek in Nepal. The symptoms alleviated by this drug are headache, nausea, dizziness, and tiredness.
It is advisable to begin taking Diamox one or two days prior to the ascent to the high altitude, to continue the medication during the trek, and for at least 48 hours after having reached the highest point of the trip, so the body can get used to the new environment.
The usual dose is 125 mg two times per day, while some people may need up to 250 mg two times per day if receiving medical advice. It is very important to take Diamox together with a lot of water or food in order to prevent nausea and to keep hydrated, because the drug can lead to an increased amount of urination and thus dehydration.
On the other hand, Diamox is not the only factor that will ensure good acclimatization. It is recommended that those who apply for the trek should use the drug as an aid, but always remember that ascending slowly, taking some rest days, and following their body signals is a way of being safe and having a more comfortable experience at high altitudes.
Before starting to use Diamox, you should seek a doctor's advice to find the most suitable dose for you and to be sure that you can have it without any problems if you have any health conditions. If the symptoms of severe altitude sickness get more pronounced, no matter what, it is critical to descend immediately.
Which is The Best Time to Take Diamox For AMS While Trekking in Nepal?
Timing
When to Take
Notes
First dose
24 to 48 hours before you begin your ascent
Induces a second mechanism for the medication to build up in the body, increasing the probability of favorable acclimatization.
Daily dosing
Every 12 hours, typically morning and evening
Commonly prescribed prophylactic dose would be 125 mg bid increasing to a maximum of 250 mg bid as prescribed.
Continuation
Continue through the first 2 to 4 days at high altitude, or until safely descending
Decreases risk for acute mountain sickness (AMS) during the early ascent phase.
To begin on a trek in Nepal, before starting your ascent to the mountains at high altitude you should take Diamox 24 to 48 hours to be sure that the medicine has saturated your system and it will help your body to acclimatize properly.
Generally, the recommended dosage is 125 mg twice a day, one in the morning and the other in the evening, however, for some it may be up to 250 mg twice daily if a doctor advises so.
Thus, it is recommended to keep taking Diamox not only at the time of the climb but also for at least 48 hours after arrival at the highest point, minimizing the symptoms, such as headache, nausea, and fatigue, which are caused by acute mountain sickness (AMS).
Actually, one dose at bedtime is necessary as it supports respiration during sleep and hence better oxygen intake.
In any case, always take the medicine along with water or food so that the side effects can be minimalized, and get it prescribed by a healthcare specialist for the suitable dosage and time in accordance with your health and trekking plan.
When To Take Diamox If you are On Your Everest Base Camp Trek?
Diamox Guide written on the Box Itself
Day
Location
Altitude (m)
Trek Activity & Approximate Trek Time
Diamox Dosage & Timing
Notes
-2
Arrival Kathmandu
1,400
Rest, prepare for trek
Start Diamox 125 mg twice daily (8AM & 8PM)
Pre-acclimatization
1
Kathmandu to Lukla, trek to Phakding
2,800 / 2,650
Flight (~30 mins) + trek 3-4 hrs
125 mg 8AM, 125 mg 8PM
Continue Diamox
2
Phakding to Namche Bazaar
3,440
Trek approx. 6-7 hrs
125 mg 8AM, 125 mg 8PM
Important acclimatization stop
3
Namche Bazaar (Acclimatization)
3,440
Rest, short hikes (~3-4 hrs)
125 mg 8AM, 125 mg 8PM
Acclimatization day
4
Namche Bazaar to Tengboche
3,860
Trek approx. 6-7 hrs
Increase to 250 mg 8AM, 250 mg 8PM if advised
Higher altitude monitoring
5
Tengboche to Dingboche
4,350
Trek approx. 5-6 hrs
250 mg 8AM, 250 mg 8PM
Continue higher dose
6
Dingboche (Acclimatization)
4,350
Rest, optional hike (~3-4 hrs)
250 mg 8AM, 250 mg 8PM
Acclimatize at altitude
7
Dingboche to Lobuche
4,930
Trek approx. 5-6 hrs
250 mg 8AM, 250 mg 8PM
Monitor symptoms
8
Lobuche to Gorak Shep/Base Camp
5,364
Trek 7-8 hrs incl. EBC visit
250 mg 8AM, 250 mg 8PM
Highest altitude day
9
Gorak Shep to Kala Patthar to Pheriche
5,550/4,240
Early morning hike (~3 hours) + trek 7-8 hrs
250 mg 8AM, 250 mg 8PM
Early start for sunrise views
10
Pheriche to Namche Bazaar
3,440
Trek approx. 6-7 hrs
Taper to 125 mg 8AM, 125 mg 8PM
Descending, monitor health
11
Namche Bazaar to Lukla
2,840
Trek approx. 7 hrs
125 mg 8AM, 125 mg 8PM
Continue tapering dose
12
Lukla to Kathmandu (Flight + Drive)
1,400
Flight ~35 mins + 5-6 hrs drive
Stop Diamox if acclimatized and symptom-free
Return day
13
Kathmandu
1,400
Rest, sightseeing
No Diamox
Recovery day
14
Departure from Kathmandu
1,400
Departure
No Diamox
Starting Diamox Before the Trek Has Begun
First start taking Diamox 24 to 48 hours before you begin the ascent to the high altitude. It helps the medicine to go through your body and thus, your body can get adjusted early.
Numerous trekkers commence the intake of Diamox 48 hours before, mostly while they are in Kathmandu, which also makes it possible for you to detect if there are any side effects.
Dosage and Timing Schedule
The recommended prevention regimen is 125 mg every 12 hours. The schedule would generally be with an 8 a.m. and 8 p.m. dosage example is:
Day 2 (Kathmandu): 125 mg morning and night at 8 a.m. and 8 p.m.
Day –1 (days rest in Kathmandu): 125 mg at 8 a.m. and 8 p.m.
Day 0 (Start trekking – Lukla, 2,860 m): 125 mg at 8 a.m. and 8 p.m.
Continue taking the 125 mg doses twice daily while on the trek, including for the 2 big stops in Namche Bazaar (~3,440 m), Dingboche (~4,410 m), all the way to Everest Base Camp (~5,364 m).
Duration of Use
Again, we recommend going on with Diamox until you are safely going down from high altitude or at least for some days after your climb to the highest point on the route. A number of trekkers discontinue the intake near Base Camp or start tapering the dose as they go down.
It is a good practice to take Diamox two days before your departure to altitude, as this helps the body become familiar with the side effects caused by a tingling sensation, which is mild and gives you a sense of security when you get to higher altitudes.
By taking it every 12 hours, you keep a constant level of the drug in the blood that helps you to acclimatize step by step. The combination of 8 a.m. and 8 p.m. dosing corresponds with practical trekking schedules and thus minimizes the necessity of urinating at night if the evening dose is taken a little earlier.
This regime is in accordance with experts' advice and personal experience of the trek to lower the risk of acute mountain sickness during the Everest Base Camp trek.
But if you are going to use Diamox, by all means, do it under a doctor's control and only as a means of assistance for the improvement of acclimatization, not as a treatment, and in combination with gradual ascent and enough water intake.
Why Does This Work?
Beginning early (2 days before) makes sure that you have adjusted to any minor symptoms (such as tingling), thus you can go to bed with a relaxed mind when the altitude goes up.
Regular 12-hour interval administration assists in keeping the drug concentration at a therapeutic level, and also gradual acclimation is supported.
Scheduling at approximately 8 a.m. and 8 p.m. is convenient as it fits with the usual trekking day, and it also reduces the need for urination if the evening dose is taken earlier.
What is Diamox?
Diamox is a medicine. In some cases, when distance climbing is involved, the high altitude causes discomfort. If the climb is too high, the air has less oxygen than usual. Due to this, some people fall sick.
Diamox accelerates accommodation to less oxygen. Thus, many trekkers prefer to administer this medicine during their mountain trekking. It is safe and quite useful if used properly.
Symptoms of Acute Mountain Sickness (AMS)
Acute Mountain Sickness can cause a number of unpleasant symptoms and can ruin your hiking/trekking trip. Usual symptoms are:
Headache
Nausea or vomiting
Dizziness or feeling faint
Shortness of breath
Fatigue or weakness
Loss of appetite
If left untreated, AMS can go on to insidious morbidities, including Chronic Obstructive Disease, High Altitude Pulmonary Edema (HAPE), and High Altitude Cerebral Edema (HACE), both of which are fatal. This is because Diamox is a routine prophylactic when trekking in Nepal; naturally, in such conditions trekkers will be able to take in and safely prepare for the trek.
What is the purpose and benefits of Diamox?
Diamox is mainly used to prevent and treat the signs and symptoms of altitude sickness, or acute mountain sickness (AMS). AMS occurs when one rises too quickly without his body having time to adjust to the altitude. Mild to severe symptoms include headache, nausea, dizziness, fatigue, and shortness of breath.
The primary use of Diamox is to speed up acclimatization to high altitude to prevent or reduce symptoms of AMS. It triggers the stimulation of breathing and increases oxygen levels in the blood. Taking Diamox, therefore, would allow a person to escape or reduce the agony and hazards that come with altitude sickness.
Why do people get altitude sickness while trekking in Nepal?
Because higher places have different air, people get altitude sickness. Going up a mountain means less oxygen in the air. Oxygen is very necessary for our bodies to operate smoothly.
At low places like at home, there is a lot of oxygen to breathe. But as you climb higher in the mountains of Nepal, the air gets thinner and you cannot get as much oxygen with each breath.
Your body is getting too little oxygen too fast and you begin feeling sick. This very sickness is called altitude sickness. You may feel headache, tired, or nauseous as altitude sickness symptoms.
The higher you go, the more you suffer due to less oxygen. That's why almost all Everest mountaineers get sick.
Altitude sickness can be frightening, but there are some remedies to feel good. Bringing people through trekking in Nepal is assisted by doctors and mountain guides in preparation for air changes.
How does Diamox help with altitude sickness?
Diamox Tablet Usage
As a pre-treatment, it helps your body in preparing for a little air. In places like Nepal when one climbs a peak high and air contains less oxygen, it rather makes a sick person.
It makes you breathe a little faster and changes some functions of the blood so that it can absorb oxygen better.
Therefore, with the help of Diamox, one can adjust to altitude more quickly, so you might feel a bit less sick and enjoy your trek more.
Therefore, Diamox makes the body essentially come to terms with low oxygen quicker. It's like a small helper to keep you safe in the mountains.
When should I start taking Diamox for my Nepal trek?
You should start taking Diamox about one or two days before you go to high places in Nepal.
Taking the medicine early helps your body get ready for the mountain air.
This way, your body can start to adjust to less oxygen before you climb higher.
Starting early can help you feel better and have less chance of getting altitude sickness.
Alternative Treatments to consider Before resorting to Diamox
While Diamox is an effective medicine against altitude sickness, other treatment options and preventive measures exist one should try before entering into Diamox. These include gradual ascent with enough acclimatization time, keeping oneself properly hydrated, and adequate rest, coupled with adequate acclimatization in between altitudes.
Remember every individual is unique; an approach that works well for one does not necessarily work for the other. Most importantly, make an appointment with a health professional or a travel medicine expert to explore alternative treatments so that the right plan is outlined for your specific case.
How much Diamox should I take? (Diamox dosage Nepal trek)
Commonly, if one is taking Diamox for altitude sickness while in Nepal, the dose would be from 125 mg to 250 mg taken twice daily. Once in the morning and once in the evening.
Starting Diamox a day or two prior to starting the ascent to the hills is always better; this way, the bodies get some time to prepare for the mountain.
The usual dose is 125 mg twice a day. Some physicians might also advise someone to take 250 mg twice a day.
This dose is taken as you ascend up the mountain; after reaching a safe height and starting to descend, you can stop taking Diamox.
The tablet might cause slight discomfort in the stomach, which can be avoided by taking it with some water or food.
Always talk with your doctor before starting any medicine, so your doctor can advise you correctly on the dosage.
If you feel dizzy or tingling after taking Diamox, that might include signs of an overdose, so you should never take extra medicine if you miss a dose.
If you feel unwell even after taking Diamox, it will be good for you to stop ascending and rest or come down a bit to recover.
Generally, the safe, usual dose of Diamox for most trekkers is 125 mg twice daily, beginning a day or two before the trek.
When to take Diamox each day? (Diamox timing trekking)
Diamox is to be administered twice in a day, preferably once in the morning and once during the night.
It gives the body in the morning time a sort of preparatory strength for climbing throughout the day. In contrast, the night dose will aid adjustment to altitude changes during sleep.
To work efficiently, it is very crucial that the medicines must be taken at the same time every single day.
Whenever you forget to take the medicine, try to take it again as soon as you remember but swerve taking two doses or consumption close together.
In this manner, Diamox counteracts symptoms and prepares the body to effectively sustain high-altitude mountain conditions encountered during trekking.
How long should I keep taking Diamox during the trek?
You should keep taking Diamox while you are going up to higher places. It helps your body get used to the thinner air.
It is good to continue taking Diamox for a few days after you reach the high places too. This lets your body adjust better and can help stop altitude sickness.
One can get sick from altitude if he stops taking Diamox too early. So, take it as your guide or doctor prescribes you, possibly until the time you descend or have stayed in that high place for a few days.
If very sick feelings come even after taking Diamox for quite a few days, better rest and possibly go lower in the mountain. Always listen to what your body says.
What to do if I feel altitude sickness even after taking Diamox?
Once you feel altitude sickness despite taking Diamox, it means your body is still struggling at the high altitude.
Pulling yourself up any higher is the worst thing you could do. It might make your sickness worse!
You should rest and allow your body to adjust to the height. If you are really sick or the symptoms become worse, a descent will act as a good cure.
Do inform a doctor or a guide about your condition; they will be tactful enough to assist and advise you on the next course of action.
Remember, the fact that you are taking Diamox does not mean you can overcome altitude sickness; never negate how your body tells you this.
Is Diamox safe for Everest trek and other high places?
Yes, Diamox is generally safe for people trekking to Everest and other high mountains. It is a drug that many climbers and trekkers use to acclimate to the high altitude thin air. It is also a common medicine for altitude sickness, which is caused by low pressure.
Anyway, taking it correctly is paramount; this means following your doctor or guide perfectly. Doing so keeps you safe. Some might get mild side effects that pass quickly.
Being advised by a medic to take Diamox is your best prophylactic being for a big mountain trek in Nepal.
What side effects can Diamox have? (Diamox side effects trek)
It's possible to have some side effects after taking Diamox. The most frequently reported sensations are a tingling and numbness of the fingertips and toes. Generally, these feelings are not painful, but they can certainly feel a little strange- or even tickly!
Another side effect is more urination. Diamox generally makes your body get rid of extra water, which creates frequent urges to go to the washroom. It is good to keep drinking lots of water to avoid dehydration.
Some could experience a slight upset stomach or a feeling of nausea. This condition is called mild nausea and usually only lasts for a short time. If it becomes bothersome, tell your doctor or guide about it.
Mostly, side effects induced by Diamox are mild and subsided as your body gets used to the medicine. But in the case you feel very uncomfortable or anything seems wrong, always consider seeing the doctor or health caregiver to be on the safe side.
How to Reduce Side Effects of Diamox?
Diamox is the most common drug prescribed for Altitude Sickness Prevention. But then it is not a magic pill. Like all medicines, Diamox also brings some unwanted side effects.
While some of them are really bothersome, a little planning can go a long way in keeping them at bay. Please note: The following tips can lessen the intensity of Diamox side effects.
Start with a Trial Dose: Take a trial dose of 125-250 mg just before you hit the trail. Try using the drug a few days before your trek. This would help you test your tolerance in the comfort of your home. Should you feel any discomfort, you can readily get assistance.
Stay Hydrated - but wisely: As a diuretic agent, Diamox will certainly make you urinate more after its intake. But, do not feel annoyed to cut back on fluids. Balance your fluid time with electrolyte intake. Use rehydration salts or drink ORS on a daily basis.
Split the Dosage: Splitting doses greatly reduce the side effects. Try taking your dosage three times a day instead of twice; 125 mg thrice a day instead of 250 mg twice will surely alleviate the tingling and stomach issues.
Time your doses wisely: Don’t take Diamox right before bed so that you don’t have to get up so often at night to go to the bathroom. Have an early morning and early evening dose. In case the dosage is split, take one in the early morning, afternoon, and early evening.
Watch for Allergies and Interactions: If you are allergic to sulfa, your doctor must be consulted. Diamox is not for you. Also check with a doctor about any other health conditions you may have when taking any kind of medication.
Eat Before Taking It: Have a meal prior to or during the dosage of Diamox. Having a meal lessens the chances of nausea or stomach upset. Trekking on an empty stomach is hard enough, so do not make it worse with medications.
Let the Tingling Pass: That pins-and-needles sensation on your fingers, toes, or lips is typically caused by Diamox and feels harmless in most cases. This feeling fades off as the body adjusts on its own. If it is very annoying and uncomfortable, talk about lowering the dose with your guide or doctor.
Avoid Alcohol: Alcohol exacerbates dehydration and intensifies the side effects of Diamox. Also, drinking alcohol at a high altitude elevates the chances of acute mountain sickness.
Who Should Avoid Diamox during the Trek?
Diamox is sometimes unsafe for certain patients and fits its use during trekking in the Nepal Himalayas. This drug should not be administered to the patient with certain concomitant medical conditions or allergies.
Do not take Diamox if you are allergic to drugs because the drug is allergenic and can sometimes bring about a secondary allergic reaction that may even be lethal. Besides, the following ailments should use Diamox or avoid its use, on strict medical supervision:
Kidney or liver disease: Diamox might aggravate some symptoms in these organs and worsen existing illnesses.
Severe respiratory problems: It probably is not suitable for persons with acute respiratory distress syndrome.
Diabetes: Diamox influences glucose and should be administered with utmost caution.
Pregnancy or Breastfeeding: The use of Diamox on a fetus or suckling infant remains poorly defined and would be avoided wherever there can be an option.
Prevention of Log-Diuresis of Acetazolamide
Acute Diamox overdosed toxicity poses the risks of severe complications and side effects; possibly even fatal, disorientation or paraesthesia of arms and legs, or respiratory distress are among them.
In preventing overdose:
Adhere to the prescribed dose and time.
Never double any additional dose-for-instance if a dose gets skipped.
Instead, take the next scheduled dose at the appointed time.
Alcohol consumption is strictly discouraged in combination with Diamox since it can promote dehydration and toxic side effects.
Neverly undermining any doctor's advice or prescription whilst walking.
Don't take any more drugs but consult a doctor when unexpected side effects or any rare circumstance arise.
Consulting with a Healthcare Professional about Diamox
If you are thinking about Diamox, it is very important that you get in touch with your doctor before you begin taking it. The doctor will be able to evaluate your individual needs while weighing its risks and benefits and will advise you accordingly and personally based on your medical history.
If you do have other questions or concerns with respect to the side effects of Diamox, interaction with other medications, or dosages for your specific case, a healthcare professional ought to be able to help you and provide direction in making an informed decision for yourself.
How to prevent altitude sickness without medicine? (Altitude sickness prevention)
Try preventing altitude sickness at all costs whenever you venture into the high mountains, including walking slowly. When you climb slowly, your body gets more time to get used to the thinner air.
The problem is that in the mountains, when people do not drink enough water, they feel worse. So, do encourage people to drink lots of water. Drinking water keeps you strong and can help you feel better. Sometimes, when you do not drink enough water, you can get sick more easily.
Though resting so often may not sound like fun, your body will be happy to take a few naps here and there while still adjusting better to the height. Time for rest and some sleep means a happier body and an easier altitude adjustment.
So walking slowly, drinking water, and resting sufficiently-evening without the aid of medication like Diamox-can help prevent altitude sickness.
Remember, these steps help your body get ready for high places and make your trekking in Nepal safer and more fun.
Why do some trekkers in Nepal take Diamox? (High altitude medicine Nepal)
Some trekkers in Nepal take a medicine called Diamox to help them feel better when they climb high mountains. When people go to places with very high altitude, like many parts of Nepal, the air has less oxygen. This can make them feel sick.
The sickness from not enough oxygen is called altitude sickness. It can cause headaches, tiredness, or feeling like you want to throw up. Because this sickness is not fun and can be dangerous, some trekkers take Diamox.
Diamox helps the body get used to the lower oxygen faster. It makes it easier to breathe and helps stop some of the sickness symptoms.
Many doctors in Nepal suggest Diamox as a good medicine when trekking in high places. It is a common way to protect yourself from feeling very sick when walking up steep mountains.
So, trekkers take Diamox to prevent altitude sickness and have a safer, happier experience climbing in Nepal.
Can children take Diamox during trekking?
Yes, children can take Diamox during trekking, but the dose needs to be smaller than for adults. Children are not just small adults. Their bodies work differently, so the medicine amount must be just right for them.
Because of this, a doctor should always decide how much Diamox a child should take. The doctor will think about the child’s age, weight, and how high they will be trekking. This helps keep the child safe and healthy.
It is important to follow the doctor’s advice carefully. If the dose is too high, the child might get bad side effects. If it is too low, the medicine may not work well.
So, if a child is going on a trek in Nepal or to other high places, the family should talk to a doctor about using Diamox. This way, the child can be protected from altitude sickness in the safest way.
Tips for safe trekking in Nepal with Diamox (Safe trekking Nepal Diamox)
Being safe and happy while trekking in Nepal depends on taking Diamox the right way. When you administer the medication, follow the timing and dosage prescribed by your doctor or guide so that the medicine can work effectively for you and keep you safe.
Learning to listen to your body is a good practice. If weakness, dizziness, or sickness sets in, common sense suggests not forging on at your normal pace. Your body is urging you to slow down and rest. Frequent breaks and slow movement will help your body to adjust to the altitude.
Hydration is also key. The body needs lots more water at high altitudes to stay healthy. Another effect of Diamox is to induce greater urination, thereby emphasizing the importance of drink lots of water to avoid dehydration.
Lastly, do not rush your trek. A fast ascent can aggravate altitude sickness. Slow ascents help your body and provide material for towing fun and safe.
So, in a nutshell, take Diamox as advised, listen to your body, drink lots of water, and take your time while trekking. Doing so will ensure a safe and fun trek in Nepal.
Hailing from the scenic expanse of Chitwan in Parsa, nestled adjacent to the enchanting Chitwan National Park, Mr. Rohit Subedi graces Adventure Altitude Treks as a seasoned Senior Accountant. Since his induction in 2018, immediately following the attainment of his master's degree, Rohit's journey has been marked by excellence. Elevating his role, our company entrusted him with the mantle of Tour Coordinator, specializing in crafting unparalleled journeys across Nepal, Tibet, and Bhutan.